Great strides have been made in the area of hydrogel science since the first hydrogels were described in the 1960s. Hydrogelation occurs in response to a physical or chemical stimulus, such as temperature, pH, electric or magnetic field, enzymatic modification, light and others. These three-dimensional networks consisting of mainly water molecules represent a unique class of materials, with many applications including cell therapeutics, cartilage/bone regeneration, sustained drug release and drug delivery systems, tissue engineering, 3D bioprinting and extracellular culture medium (ECM) for cancer cells, stem cells and neuronal cells. ChemBioGels 2021 will feature on-going work in the area of hydrogel science.
Great strides have been made in the area of hydrogel science since the first hydrogels were described in the 1960s. Hydrogelation occurs in response to a physical or chemical stimulus, such as temperature, pH, electric or magnetic field, enzymatic modification, light and others. These three-dimensional networks consisting of mainly water molecules represent a unique class of materials, with many applications including cell therapeutics, cartilage/bone regeneration, sustained drug release and drug delivery systems, tissue engineering, 3D bioprinting and extracellular culture medium (ECM) for cancer cells, stem cells and neuronal cells. ChemBioGels 2021 will feature on-going work in the area of hydrogel science.
Great strides have been made in the area of hydrogel science since the first hydrogels were described in the 1960s. Hydrogelation occurs in response to a physical or chemical stimulus, such as temperature, pH, electric or magnetic field, enzymatic modification, light and others. These three-dimensional networks consisting of mainly water molecules represent a unique class of materials, with many applications including cell therapeutics, cartilage/bone regeneration, sustained drug release and drug delivery systems, tissue engineering, 3D bioprinting and extracellular culture medium (ECM) for cancer cells, stem cells and neuronal cells. ChemBioGels 2021 will feature on-going work in the area of hydrogel science.
Professor Ehud Gazit
Professor Ehud Gazit
Professor Bing Xu
Enzymatic Noncovalent Synthesis of Supramolecular Assemblies for Targeting Subcellular Organelles
Short Abstract:
Subcellular compartmentalization is a key feature of eukaryotic cells. Selectively targeting subcellular compartments, though holding many exciting opportunities for biomedicine, remains rather underdeveloped. Enzyme noncovalent synthesis (ENS), an approach that integrate enzymatic reactions and self-assembly, provides a new way for subcellular targeting. In this talk, we briefly introduce the development of supramolecular self-assemblies for targeting mitochondria, endoplasmic reticulum, Golgi apparatus, nucleus, and cell membrane. We mainly focus on the use ENS of peptide assemblies, which spatiotemporally controls the formation of supramolecular nanofibers, for subcellular targeting and its applications, such as developing novel cancer therapeutics.
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Short CV:
After receiving his BS and MS from Nanjing University in 1987 and 1990, Bing Xu obtained his PhD in 1996 from the University of Pennsylvania. Before starting his independent research at the Hong Kong University of Science and Technology (HKUST) on the Aug. 2000, he was an NIH postdoctoral fellow at Harvard University. He was tenured as an associated professor in Jan 2006 and became a full professor in July 2008 at HKUST. Bing Xu currently is a professor in the Department of Chemistry, Brandeis University. His research focuses on the applications of molecular engineering in materials, biology, and medicine.